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KMID : 1123920030170020549
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Korean Journal of Oriental Physiology and Pathology
2003 Volume.17 No. 2 p.549 ~ p.552
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Effects of Sophorae Radix Extract in Pulmonary Vascular Endothelial Cells Damaged by XO/HX
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Kwon Kang-Beom
Lee Ho-Seung
Kim In-Su
Kim In-Gyu
Ryu Do-Gon
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Abstract
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To investigate the protective effect of Sophorae Radix (SR) on the damage by pulmonary vascular endothelial cells by xanthine oxidase (XO)/hypoxanthine (HX)-induced oxygen tree radical, Neutral Red (NR) and c-fos immunopositive cell assay were used. The results were obtained as follows ; The viability of vascular endothelial cells treated with XO/HX was decreased. And c-fos immunopositive cells represented a maximal increase in group treated with XO/HX for 2 hour in pulmonary vasvular endothelial cells. But pretreated groups with SR extracts were not inhibited the increase of c-fos immunopositive cells by XO/HX in a dose-dependent manner. These results show that XO/HX elicits toxic effects in cultured pulmonary vascular endothelial cells, and suggest that SR extract is very effective in the prevention of XO/HX-induced increase of c-fos immunopositive cells.
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KEYWORD
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Sophorae Radix(苦蔘), Neutral Red, c-fos immunopositive cells, xanthine oxidase/hypoxanthine
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